Dwarfs will rule the world!

Well, no, dwarfs may not rule the world. There is a good chance a certain group will outlive their contemporaries though. This recent study out of the University of Southern California studied a group of dwarfs who have Laron syndrome in Ecuador and worldwide. Laron syndrome is genetic and effects how growth is regulated in the body.

The individuals have Laron syndrome, a rare disease that causes stunted growth in about 250 people worldwide. Scientists have known the syndrome results from a mutation in a gene that regulates how cells grow and divide.

The dwarfism cause is also a barrier to cancer and diabetes. The disease limiting culprit in Laron's cases appears to be an insulin producing protein that binds with human growth hormone, insulin-like growth factor 1 or IGF1.

High levels of IGF1 have been implicated in cancer and diabetes in previous studies, and low levels have been found to cause increased longevity in everything from yeast and worms to mice.

"In worms, we don't see diabetes or cancer or anything — once we establish this potential [to extend life] in worms, we moved to mice," said Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aging. "We do see similar things in this study [of humans], and it validates everything we do."

Sure enough, in the short-statured Ecuadorean group, the study revealed that deficient growth hormone receptor led to low levels of IGF1, and this was associated with the disease-resistance.

The final intention is development of a drug that will mimic reduced IGF1 in healthy individuals reducing cancer and diabetes.

Interesting concept, but I would guess other negative side effects would appear besides the positive reduction in cancer rates and diabetes. Wikipedia states one of the disease's symptoms in men puts fear in almost any healthy male,

.....a very small penis.

Wine and weight control

Many studies concerning weight gain and loss are always being published. This study recently published is about moderate alcohol consumption and weight gain by women. It hints that alcohol in the subject's diet reduced weight gain. Once again, the supposed evil things in life may help us in moderation. It may help explain the French conundrum of eating rich foods and staying thin (French drink wine). In a prior post, I discussed how cheese has the chemical compound linoleic acid that increases a person's metabolism slightly reducing weight gain. What are the exact benefits to moderate alcohol consumption?

First of all, heavy alcohol consumption is NOT good for anyone. It leads to weight gain and other various chronic health problems. Societal problems also arise with the inability to properly function among people. Alcoholism goes down all the bad paths your mother warned you about. I condemn daily drinking of 3 or more drinks in a setting. Even more damaging to a person's body is binge drinking at 5+ drinks in one setting. We as a society should find ways to reduce such drinking.

Moderation in all things. Drinking a couple of drinks a day will not hurt you. The study linked above followed 19,220 women aged 39 and older who started with a normal body mass index or healthy body weight. The study followed these women 13 years and found:

"An inverse association between alcohol intake and risk of becoming overweight or obese was noted for all four types of alcoholic beverages [red wine, white wine, beer and liquor], with the strongest association found for red wine and a weak yet significant association for white wine after multivariate adjustment," the authors write.

Very interesting. The exact reason why is not speculated in the article. It is another study that questions the dietary orthodoxy we are often hear. We need more studies like this example.