Dwarfs will rule the world!

Well, no, dwarfs may not rule the world. There is a good chance a certain group will outlive their contemporaries though. This recent study out of the University of Southern California studied a group of dwarfs who have Laron syndrome in Ecuador and worldwide. Laron syndrome is genetic and effects how growth is regulated in the body.

The individuals have Laron syndrome, a rare disease that causes stunted growth in about 250 people worldwide. Scientists have known the syndrome results from a mutation in a gene that regulates how cells grow and divide.

The dwarfism cause is also a barrier to cancer and diabetes. The disease limiting culprit in Laron's cases appears to be an insulin producing protein that binds with human growth hormone, insulin-like growth factor 1 or IGF1.

High levels of IGF1 have been implicated in cancer and diabetes in previous studies, and low levels have been found to cause increased longevity in everything from yeast and worms to mice.

"In worms, we don't see diabetes or cancer or anything — once we establish this potential [to extend life] in worms, we moved to mice," said Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aging. "We do see similar things in this study [of humans], and it validates everything we do."

Sure enough, in the short-statured Ecuadorean group, the study revealed that deficient growth hormone receptor led to low levels of IGF1, and this was associated with the disease-resistance.

The final intention is development of a drug that will mimic reduced IGF1 in healthy individuals reducing cancer and diabetes.

Interesting concept, but I would guess other negative side effects would appear besides the positive reduction in cancer rates and diabetes. Wikipedia states one of the disease's symptoms in men puts fear in almost any healthy male,

.....a very small penis.